Experiences with larger message sizes

By any chance has anyone worked with using Kafka with message sizes that are approximately 50MB in size?  Based on from some of the previous threads there are probably some concerns on memory pressure due to the compression on the broker and decompression on the consumer and a best practices on ensuring batch size (to ultimately not have the compressed message exceed message size limit).  

Any other best practices or thoughts concerning this scenario?

Thanks!
Denny